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Chastity and female hormones.
1) Put her in chastity (plastic, dull spiked cage is ideal).
2) Catheterize her boyclit.
3) Every day, put on some latex gloves, take a big fingerful of female estrogen cream (like Premarin) and force it into her pussy.
Don't fuck her after filling her pussy with Premarin, because it will absorb into your skin. Put a plug in her and wait 12 hours. After you fuck her (daily), give her some more Premarin and reinsert the plug. This is good because she will learn to enjoy constant anal presence (CAP), which will allow you to rape her at any time.
Remember to constantly torture and irritate her nipples, and engage in throat training for depth at least twice a day. I also recommend applying pressure and electrostim to her balls very frequently. You might be tempted to apply rapid, forceful pressure, but slowly building, dull pressure is actually more realistic, and ideal for long-term application. Eventually, she will learn to cum from anal and ball torture. At this point, she will be broken, and you can whore her out to black men, dogs, and horses.